Protein Details: Potassium voltage-gated channel subfamily G member 3

Protein ID

ICDB_Pro_1313

Protein Name

Potassium voltage-gated channel subfamily G member 3

Gene Name

KCNG3

Organism

Homo sapiens (Human)

Length

436 amino acids

AlphaFoldDB

AF-Q8TAE7-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1.

Sequence

MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSTEFLN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Brown-Vialetto-Van Laere Syndrome 1 and Thymoma Type B2

Location

Expressed in the brain; liver; testis; small intestine; colon; thymus and adrenal gland (PubMed:11852086; PubMed:12060745).

DOI ID

10.1016/s0014-5793(02)02267-6; 10.1073/pnas.122617999; 10.1038/nature03466; 10.1101/gr.2596504; 10.1074/jbc.m808786200

RefSeq

NP_579875.1 [Q8TAE7-1]; NP_758847.1 [Q8TAE7-2]